The risk or severity of adverse effects can be increased when Sertraline is combined with Ergonovine. Sertraline may increase the hypoglycemic activities of Insulin Lispro. Sertraline may increase the hypoglycemic activities of Glipizide. The risk or severity of adverse effects can be increased when Prilocaine is combined with Sertraline. The metabolism of Loratadine can be decreased when combined with Sertraline. Sertraline may increase the hypoglycemic activities of Tolazamide. Dextromoramide may increase the serotonergic activities of Sertraline. The risk or severity of adverse effects can be increased when Sertraline is combined with Bromocriptine. The metabolism of Sertraline can be decreased when combined with Topiroxostat. The serum concentration of Clozapine can be increased when it is combined with Sertraline. Sertraline may increase the QTc-prolonging activities of Chloroquine. The metabolism of Hydrocodone can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Trimethoprim. The metabolism of Antipyrine can be decreased when combined with Sertraline. The metabolism of Flunarizine can be decreased when combined with Sertraline. The metabolism of Phenformin can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Tipranavir. The risk or severity of adverse effects can be increased when Ezogabine is combined with Sertraline. The risk or severity of adverse effects can be increased when Sertraline is combined with Perospirone. The metabolism of Cariprazine can be decreased when combined with Sertraline. Sertraline may increase the hypoglycemic activities of Canagliflozin. The metabolism of Ambrisentan can be decreased when combined with Sertraline. Pivhydrazine may increase the serotonergic activities of Sertraline. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Sertraline. The risk or severity of adverse effects can be increased when Fospropofol is combined with Sertraline. Sertraline may increase the antiplatelet activities of Acetylsalicylic acid. The serum concentration of Sertraline can be decreased when it is combined with Mitotane. Sertraline may increase the serotonergic activities of Methylene blue. The risk or severity of adverse effects can be increased when Selegiline is combined with Sertraline. The metabolism of Halothane can be decreased when combined with Sertraline. Sertraline may increase the hypoglycemic activities of Pioglitazone. The metabolism of Sertraline can be decreased when combined with Olaparib. The risk or severity of bleeding can be increased when Betrixaban is combined with Sertraline. The metabolism of Gliclazide can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Verapamil. The metabolism of Methoxyflurane can be decreased when combined with Sertraline. The metabolism of Ipratropium bromide can be decreased when combined with Sertraline. Sertraline may increase the hypoglycemic activities of Miglitol. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Sertraline. Sertraline may increase the hypoglycemic activities of Acarbose. The metabolism of Sertraline can be decreased when combined with Modafinil. Dezocine may increase the serotonergic activities of Sertraline. The risk or severity of adverse effects can be increased when Ketazolam is combined with Sertraline. Tropisetron may increase the serotonergic activities of Sertraline. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Sertraline. The serum concentration of Sertraline can be increased when it is combined with Ivacaftor. The metabolism of Betaxolol can be decreased when combined with Sertraline. The metabolism of Methamphetamine can be decreased when combined with Sertraline. The risk or severity of adverse effects can be increased when Flibanserin is combined with Sertraline. The metabolism of Sparteine can be decreased when combined with Sertraline. The risk or severity of adverse effects can be increased when Venlafaxine is combined with Sertraline. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Sulfisoxazole. The risk or severity of adverse effects can be increased when Enflurane is combined with Sertraline. The risk or severity of adverse effects can be increased when Sertraline is combined with Protriptyline. Sertraline may increase the QTc-prolonging activities of Escitalopram. The risk or severity of adverse effects can be increased when Moricizine is combined with Sertraline. The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Sertraline. The metabolism of Tofacitinib can be decreased when combined with Sertraline. Dihydroetorphine may increase the serotonergic activities of Sertraline. The metabolism of Remoxipride can be decreased when combined with Sertraline. The metabolism of Sevoflurane can be decreased when combined with Sertraline. The serum concentration of Sertraline can be decreased when it is combined with Darunavir. Sertraline may increase the QTc-prolonging activities of Anagrelide. The metabolism of Debrisoquin can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Posaconazole. The serum concentration of Metoprolol can be increased when it is combined with Sertraline. Sertraline may increase the QTc-prolonging activities of Bedaquiline. The metabolism of Prochlorperazine can be decreased when combined with Sertraline. Sertraline may increase the QTc-prolonging activities of Vandetanib. The metabolism of Rosuvastatin can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Delavirdine. The serum concentration of Sertraline can be increased when it is combined with Stiripentol. The risk or severity of adverse effects can be increased when Sertraline is combined with Desmopressin. The metabolism of Warfarin can be decreased when combined with Sertraline. Sertraline may increase the QTc-prolonging activities of Leuprolide. The serum concentration of Sertraline can be increased when it is combined with Abiraterone. The metabolism of Sertraline can be decreased when combined with Cholecalciferol. The serum concentration of Befunolol can be increased when it is combined with Sertraline. The serum concentration of Sertraline can be decreased when it is combined with Peginterferon alfa-2b. The metabolism of Zidovudine can be decreased when combined with Sertraline. The metabolism of Ramelteon can be decreased when combined with Sertraline. The metabolism of Carteolol can be decreased when combined with Sertraline. Sertraline may increase the QTc-prolonging activities of Chlorpromazine. The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Sertraline. The risk or severity of adverse effects can be increased when Lorazepam is combined with Sertraline. The metabolism of Sertraline can be increased when combined with Pentobarbital. The metabolism of Ketobemidone can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Irbesartan. Pheniprazine may increase the serotonergic activities of Sertraline. The risk or severity of adverse effects can be increased when Hydroxyzine is combined with Sertraline. Lithium may increase the serotonergic activities of Sertraline. The metabolism of Nicergoline can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Terbinafine. The risk or severity of adverse effects can be increased when Sertraline is combined with Pipamperone. The metabolism of Valproic Acid can be decreased when combined with Sertraline. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Sertraline. Sertraline may increase the hyponatremic activities of Chlorothiazide. Sertraline may increase the QTc-prolonging activities of Moxifloxacin. The risk or severity of adverse effects can be increased when Sertraline is combined with Raclopride. The metabolism of Fluvastatin can be decreased when combined with Sertraline. The risk or severity of adverse effects can be increased when Norflurane is combined with Sertraline. Sertraline may increase the antiplatelet activities of Rofecoxib. The serum concentration of Talinolol can be increased when it is combined with Sertraline. Alfentanil may increase the serotonergic activities of Sertraline. The risk or severity of adverse effects can be increased when Trazodone is combined with Sertraline. The metabolism of Tacrolimus can be decreased when combined with Sertraline. Sertraline may increase the QTc-prolonging activities of Paliperidone. The serum concentration of Atenolol can be increased when it is combined with Sertraline. The metabolism of Amoxicillin can be decreased when combined with Sertraline. The risk or severity of adverse effects can be increased when Fentanyl is combined with Sertraline. The risk or severity of adverse effects can be increased when Sertraline is combined with Harmaline. The risk or severity of adverse effects can be increased when Benzocaine is combined with Sertraline. Sertraline may increase the anticoagulant activities of Phenindione. The risk or severity of adverse effects can be increased when Fexofenadine is combined with Sertraline. The metabolism of Hexobarbital can be decreased when combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Diphenhydramine. The risk or severity of adverse effects can be increased when Sertraline is combined with Lurasidone. Safrazine may increase the serotonergic activities of Sertraline. The metabolism of Sertraline can be decreased when combined with Atomoxetine. Sertraline may increase the hypoglycemic activities of Pramlintide. The risk or severity of adverse effects can be increased when Sertraline is combined with Bifeprunox. The metabolism of Melatonin can be decreased when combined with Sertraline. The risk or severity of adverse effects can be increased when Sertraline is combined with Benperidol. Sertraline may increase the QTc-prolonging activities of Artemether. The risk or severity of adverse effects can be increased when Oxethazaine is combined with Sertraline. The metabolism of Sertraline can be decreased when combined with Isoniazid. Sertraline may increase the hyponatremic activities of Chlorthalidone. Nialamide may increase the serotonergic activities of Sertraline. The metabolism of Trabectedin can be decreased when combined with Sertraline.