The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Sulfacetamide. The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfacetamide. The risk or severity of adverse effects can be increased when Sulfacetamide is combined with Mecamylamine. The risk or severity of adverse effects can be increased when Methenamine is combined with Sulfacetamide.