Drug combination: Pregabalin sandoz & Fentanyl mylan & Midazolam accord

Compared drugs
Pregabalin sandoz (pregabalin)
Fentanyl mylan (fentanyl)
Midazolam accord (midazolam)
Drug Interaction
Pregabalin sandoz & Fentanyl mylan
The therapeutic efficacy of Fentanyl can be increased when used in combination with Pregabalin.

Pregabalin sandoz & Midazolam accord
The therapeutic efficacy of Midazolam can be increased when used in combination with Pregabalin.

Fentanyl mylan & Midazolam accord
The risk or severity of adverse effects can be increased when Midazolam is combined with Fentanyl.

Food interactions and other recommendations

Pregabalin sandoz: Avoid alcohol (may increase CNS effects). When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.
Fentanyl mylan: Avoid alcohol.
Midazolam accord: Grapefruit juice slows the product's absorption and significantly increases its bioavailability.
 
Combination of side effects
Combination of common side effects of all medicines
Headache
Pregabalin sandoz (very common)
Fentanyl mylan (common)
Midazolam accord (common)

Nausea
Pregabalin sandoz (very common)
Fentanyl mylan (very common)
Midazolam accord (uncommon)

Itching
Pregabalin sandoz (common)
Fentanyl mylan (uncommon)
Midazolam accord (uncommon)

Vomiting
Pregabalin sandoz (common)
Fentanyl mylan (uncommon)
Midazolam accord (uncommon)

Somnolence
Pregabalin sandoz (very common)
Fentanyl mylan (very common)
Midazolam accord (common)


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