The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Doxycycline. The risk or severity of adverse effects can be increased when Butethal is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pramocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methadone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Normethadone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Indinavir. The risk or severity of adverse effects can be increased when Fospropofol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sepranolone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ticlopidine. The serum concentration of Zonisamide can be increased when it is combined with Simeprevir. The risk or severity of adverse effects can be increased when Ketazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methoxyflurane is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Osimertinib. The risk or severity of adverse effects can be increased when Articaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clidinium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pimozide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butabarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alprazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flibanserin. The risk or severity of adverse effects can be increased when Amitriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pentazocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Morphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Reserpine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Propofol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fluspirilene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine. The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Benzocaine is combined with Zonisamide. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Tetracaine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Vemurafenib. The risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Felbamate. The risk or severity of adverse effects can be increased when Ketobemidone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Sildenafil. The metabolism of Zonisamide can be decreased when combined with Clarithromycin. The metabolism of Zonisamide can be decreased when combined with Telaprevir. The metabolism of Zonisamide can be decreased when combined with Nefazodone. The risk or severity of adverse effects can be increased when Agomelatine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Aprepitant. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desipramine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Brexpiprazole. The risk or severity of adverse effects can be increased when Benperidol is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide. The risk or severity of adverse effects can be increased when Secobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. The risk or severity of adverse effects can be increased when Perazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfaxalone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Rufinamide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Paliperidone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Prazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Vigabatrin. The risk or severity of adverse effects can be increased when Prilocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Raclopride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etifoxine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Zimelidine. The risk or severity of adverse effects can be increased when Halazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pizotifen. The risk or severity of adverse effects can be increased when Adipiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Drotebanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol. Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Tocilizumab. The risk or severity of adverse effects can be increased when Trichloroethylene is combined with Zonisamide. Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Opium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Carbinoxamine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Delavirdine. The risk or severity of adverse effects can be increased when Imipramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lithium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thiamylal is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Rucaparib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dimenhydrinate. The risk or severity of adverse effects can be increased when Zonisamide is combined with Maprotiline. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The risk or severity of adverse effects can be increased when Molindone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Isradipine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levodopa. The risk or severity of adverse effects can be increased when Indiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Brotizolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zaleplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Primidone. The risk or severity of adverse effects can be increased when Hexobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Eszopiclone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. Zonisamide may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Dabrafenib. The risk or severity of adverse effects can be increased when Oxycodone is combined with Zonisamide. Zonisamide may increase the sedative activities of Rotigotine. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocetirizine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Trazodone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Buspirone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Idelalisib. The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Haloperidol is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Bosentan. The risk or severity of adverse effects can be increased when Nortriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Nilotinib. The metabolism of Zonisamide can be increased when combined with Nevirapine.