The risk or severity of adverse effects can be increased when Thiopental is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Mianserin. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocabastine. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ritanserin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Secobarbital is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Palbociclib. The serum concentration of Cilostazol can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Agomelatine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Mifepristone. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flunarizine. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amoxapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quetiapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Aceprometazine is combined with Zonisamide. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tiagabine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Carisoprodol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Lopinavir. The risk or severity of adverse effects can be increased when Etizolam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Olaparib. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Escitalopram. The risk or severity of adverse effects can be increased when Clonidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Proparacaine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The risk or severity of adverse effects can be increased when Alphaprodine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Ivacaftor. The risk or severity of adverse effects can be increased when Tolcapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Efavirenz is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Luliconazole. The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Indiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pramocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amisulpride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tizanidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prilocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Mesoridazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flurazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trimipramine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Zonisamide is combined with Citalopram. Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifabutin. The risk or severity of adverse effects can be increased when Methoxyflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cetirizine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desloratadine. The risk or severity of adverse effects can be increased when Chloroprocaine is combined with Zonisamide. The serum concentration of Conivaptan can be increased when it is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Idelalisib. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perphenazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Isavuconazonium. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thiamylal is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketamine is combined with Zonisamide. Zonisamide may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Oxazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethosuximide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Isoflurane is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. The risk or severity of adverse effects can be increased when Tetracaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loprazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Tasimelteon. The risk or severity of adverse effects can be increased when Clidinium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flupentixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Delavirdine. Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Primidone. The metabolism of Zonisamide can be decreased when combined with Voriconazole. Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. Zonisamide may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ecopipam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Remifentanil is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Saquinavir. The risk or severity of adverse effects can be increased when Zonisamide is combined with Vigabatrin. The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Zonisamide. Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Methadone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxprenolol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dantrolene. The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Posaconazole. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Pregabalin. The serum concentration of Zonisamide can be decreased when it is combined with Tocilizumab. The metabolism of Zonisamide can be decreased when combined with Doxycycline. The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine. The serum concentration of Zonisamide can be decreased when it is combined with St. John's Wort. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levodopa. The risk or severity of adverse effects can be increased when Tandospirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sulpiride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pipotiazine. The risk or severity of adverse effects can be increased when Olopatadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ranolazine. The risk or severity of adverse effects can be increased when Lofentanil is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Netupitant. The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine. The risk or severity of adverse effects can be increased when Methapyrilene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Aripiprazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bromazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tiapride is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifampicin.