The risk or severity of adverse effects can be increased when Methapyrilene is combined with Topiramate. The serum concentration of Cilostazol can be increased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Pirenzepine is combined with Topiramate. The risk or severity of adverse effects can be increased when Loxapine is combined with Topiramate. The metabolism of Warfarin can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Nitrazepam is combined with Topiramate. The serum concentration of Methallenestril can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Pizotifen. The risk or severity of adverse effects can be increased when Topiramate is combined with Pomalidomide. The metabolism of Glucosamine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Ziconotide. The risk or severity of adverse effects can be increased when Tandospirone is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Fexofenadine. The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Topiramate. The metabolism of Chlorpropamide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Topiramate. The risk or severity of adverse effects can be increased when Brotizolam is combined with Topiramate. The risk or severity of adverse effects can be increased when Fospropofol is combined with Topiramate. The risk or severity of adverse effects can be increased when Gabapentin is combined with Topiramate. Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The metabolism of Ticlopidine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Topiramate. The metabolism of Timolol can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Clonazepam. The metabolism of Tolbutamide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Ziprasidone is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Valproic Acid. The metabolism of Oxiconazole can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Articaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Ramelteon. The serum concentration of Saxagliptin can be decreased when it is combined with Topiramate. Furosemide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Topiramate. The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Topiramate. Etacrynic acid may increase the hypokalemic activities of Topiramate. The metabolism of Ixazomib can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Quetiapine is combined with Topiramate. The risk or severity of adverse effects can be increased when Oxybutynin is combined with Topiramate. The risk or severity of adverse effects can be increased when Ketazolam is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Pipotiazine. The risk or severity of adverse effects can be increased when Pethidine is combined with Topiramate. The risk or severity of adverse effects can be increased when Darifenacin is combined with Topiramate. The risk or severity of adverse effects can be increased when Reserpine is combined with Topiramate. The risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Flupentixol is combined with Topiramate. The risk or severity of adverse effects can be increased when Raclopride is combined with Topiramate. The serum concentration of Aripiprazole can be decreased when it is combined with Topiramate. The metabolism of Trimethadione can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Levocetirizine. The risk or severity of adverse effects can be increased when Atropine is combined with Topiramate. Trichlormethiazide may increase the hypokalemic activities of Topiramate. The metabolism of Verapamil can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Desloratadine is combined with Topiramate. The risk or severity of adverse effects can be increased when Methadone is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Tetrabenazine. The metabolism of Gliclazide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Paliperidone is combined with Topiramate. The risk or severity of adverse effects can be increased when Perospirone is combined with Topiramate. The risk or severity of adverse effects can be increased when Benzatropine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Tasimelteon. The risk or severity of adverse effects can be increased when Fluspirilene is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Stiripentol. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. The metabolism of Macitentan can be decreased when combined with Topiramate. The metabolism of Aprepitant can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Milnacipran. The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Topiramate resulting in a loss in efficacy. The risk or severity of adverse effects can be increased when Butabarbital is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Dapoxetine. The risk or severity of adverse effects can be increased when Scopolamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Fencamfamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Thiopental is combined with Topiramate. The risk or severity of adverse effects can be increased when Pipamperone is combined with Topiramate. The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Levocabastine. The risk or severity of adverse effects can be increased when Promazine is combined with Topiramate. The serum concentration of Conjugated estrogens can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Thiamylal is combined with Topiramate. The risk or severity of adverse effects can be increased when Procyclidine is combined with Topiramate. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Topiramate. The risk or severity of adverse effects can be increased when Trazodone is combined with Topiramate. The risk or severity of adverse effects can be increased when Biperiden is combined with Topiramate. The metabolism of Lorcaserin can be decreased when combined with Topiramate. The metabolism of Diltiazem can be decreased when combined with Topiramate. The metabolism of Amiodarone can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Topiramate. The serum concentration of Gestodene can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Flunarizine. The risk or severity of adverse effects can be increased when Etifoxine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Entacapone. The risk or severity of adverse effects can be increased when Topiramate is combined with Doxepin. The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Topiramate. Droperidol may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The risk or severity of adverse effects can be increased when Halazepam is combined with Topiramate. Bumetanide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Molindone is combined with Topiramate. The risk or severity of adverse effects can be increased when Ritanserin is combined with Topiramate. The serum concentration of Etonogestrel can be decreased when it is combined with Topiramate. Indapamide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Oxethazaine is combined with Topiramate. The metabolism of Mephenytoin can be decreased when combined with Topiramate. The serum concentration of Lynestrenol can be decreased when it is combined with Topiramate. The metabolism of Atomoxetine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Cocaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Opium is combined with Topiramate. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Chlorzoxazone. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The serum concentration of Rilpivirine can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Flibanserin. The risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Topiramate. The risk or severity of adverse effects can be increased when Perphenazine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Triprolidine. The risk or severity of adverse effects can be increased when Halothane is combined with Topiramate. The risk or severity of adverse effects can be increased when Quinidine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Carbinoxamine. The risk or severity of adverse effects can be increased when Olanzapine is combined with Topiramate. The risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Topiramate. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Topiramate. The risk or severity of adverse effects can be increased when clomethiazole is combined with Topiramate. The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Topiramate. The serum concentration of Phenytoin can be increased when it is combined with Topiramate. The metabolism of Dexlansoprazole can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Allopregnanolone is combined with Topiramate. The risk or severity of adverse effects can be increased when Remoxipride is combined with Topiramate. The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Iloperidone. The metabolism of Artemether can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Dimenhydrinate.