The metabolism of Aminophenazone can be decreased when combined with Topiramate. The serum concentration of Ulipristal can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Aclidinium is combined with Topiramate. The metabolism of Moclobemide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Duloxetine. The risk or severity of adverse effects can be increased when Topiramate is combined with Maprotiline. The risk or severity of adverse effects can be increased when Topiramate is combined with Valproic Acid. The risk or severity of adverse effects can be increased when Tiapride is combined with Topiramate. The risk or severity of adverse effects can be increased when Normethadone is combined with Topiramate. The risk or severity of adverse effects can be increased when Methapyrilene is combined with Topiramate. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Topiramate. The risk or severity of adverse effects can be increased when Butethal is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Methocarbamol. The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Topiramate. The metabolism of Clarithromycin can be decreased when combined with Topiramate. Hydroflumethiazide may increase the hypokalemic activities of Topiramate. Piretanide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Pentobarbital is combined with Topiramate. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The metabolism of Rabeprazole can be decreased when combined with Topiramate. The serum concentration of Rilpivirine can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Mecamylamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Indalpine. The metabolism of Sertraline can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Propoxycaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Methscopolamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Nortriptyline. The risk or severity of adverse effects can be increased when Topiramate is combined with Cetirizine. The risk or severity of adverse effects can be increased when Perphenazine is combined with Topiramate. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Butamben is combined with Topiramate. Chlorthalidone may increase the hypokalemic activities of Topiramate. The metabolism of Arformoterol can be decreased when combined with Topiramate. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The risk or severity of adverse effects can be increased when Melatonin is combined with Topiramate. The risk or severity of adverse effects can be increased when DPDPE is combined with Topiramate. The metabolism of Dextromethorphan can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Methsuximide. The metabolism of Selegiline can be decreased when combined with Topiramate. The serum concentration of Dienestrol can be decreased when it is combined with Topiramate. The metabolism of Trabectedin can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Topiramate. The risk or severity of adverse effects can be increased when Tropicamide is combined with Topiramate. The risk or severity of adverse effects can be increased when Tetracaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Methaqualone is combined with Topiramate. The metabolism of Famotidine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Homatropine is combined with Topiramate. The metabolism of Venlafaxine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Trazodone is combined with Topiramate. The risk or severity of adverse effects can be increased when Solifenacin is combined with Topiramate. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. The metabolism of Tolbutamide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Difenoxin. The risk or severity of adverse effects can be increased when Amisulpride is combined with Topiramate. The risk or severity of adverse effects can be increased when Nitrazepam is combined with Topiramate. The risk or severity of adverse effects can be increased when Trospium is combined with Topiramate. The risk or severity of adverse effects can be increased when Oxethazaine is combined with Topiramate. The metabolism of Macitentan can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Clonazepam. The serum concentration of Ethynodiol diacetate can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Ecgonine is combined with Topiramate. The metabolism of Atomoxetine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Perospirone is combined with Topiramate. The risk or severity of adverse effects can be increased when Etorphine is combined with Topiramate. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Topiramate. The risk or severity of adverse effects can be increased when Umeclidinium is combined with Topiramate. The serum concentration of Norgestrel can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Topiramate. The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Topiramate. The risk or severity of adverse effects can be increased when Norflurane is combined with Topiramate. The risk or severity of adverse effects can be increased when Estazolam is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Dapoxetine. The metabolism of Gliclazide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Butorphanol is combined with Topiramate. The risk or severity of adverse effects can be increased when Pimozide is combined with Topiramate. The risk or severity of adverse effects can be increased when Amobarbital is combined with Topiramate. The risk or severity of adverse effects can be increased when Gabapentin is combined with Topiramate. The risk or severity of adverse effects can be increased when Biperiden is combined with Topiramate. Chlorothiazide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Topiramate. The metabolism of Eletriptan can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Dexbrompheniramine. The serum concentration of Topiramate can be decreased when it is combined with Fosphenytoin. The metabolism of Diltiazem can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Barbital is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Ethotoin. The risk or severity of adverse effects can be increased when Topiramate is combined with Clomipramine. The risk or severity of adverse effects can be increased when Lidocaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Tandospirone is combined with Topiramate. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Topiramate. Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Topiramate. Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The risk or severity of adverse effects can be increased when Perazine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Carisoprodol. The risk or severity of adverse effects can be increased when Oxprenolol is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Ethosuximide. The risk or severity of adverse effects can be increased when Articaine is combined with Topiramate. The metabolism of Ranitidine can be decreased when combined with Topiramate. Methyclothiazide may increase the hypokalemic activities of Topiramate. The serum concentration of Estrone sulfate can be decreased when it is combined with Topiramate. Cyclopenthiazide may increase the hypokalemic activities of Topiramate. The serum concentration of Drospirenone can be decreased when it is combined with Topiramate. The serum concentration of Etonogestrel can be decreased when it is combined with Topiramate. The metabolism of Amiodarone can be decreased when combined with Topiramate. The serum concentration of Norelgestromin can be decreased when it is combined with Topiramate. The metabolism of Podofilox can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Acepromazine is combined with Topiramate. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Topiramate. The risk or severity of adverse effects can be increased when Remifentanil is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Metformin. The metabolism of Rosuvastatin can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Ritanserin is combined with Topiramate. The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Topiramate. The risk or severity of adverse effects can be increased when Desloratadine is combined with Topiramate. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Topiramate. The metabolism of Enfuvirtide can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Oxazepam is combined with Topiramate. The risk or severity of adverse effects can be increased when Vecuronium is combined with Topiramate. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Topiramate. The risk or severity of adverse effects can be increased when Etifoxine is combined with Topiramate. The risk or severity of adverse effects can be increased when Levorphanol is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Tasimelteon. The serum concentration of Lynestrenol can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Oxycodone is combined with Topiramate. The metabolism of Propranolol can be decreased when combined with Topiramate. Minocycline may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The risk or severity of adverse effects can be increased when Procaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Loxapine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Nefazodone.