The risk or severity of adverse effects can be increased when Flurazepam is combined with Topiramate. The metabolism of Prasugrel can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Topiramate. Ethanol may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The metabolism of Ticlopidine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Imipramine. The serum concentration of Phenytoin can be increased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Estazolam is combined with Topiramate. The metabolism of Atomoxetine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Olanzapine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Tizanidine. The risk or severity of adverse effects can be increased when Pipecuronium is combined with Topiramate. The risk or severity of adverse effects can be increased when Norflurane is combined with Topiramate. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Glutethimide is combined with Topiramate. Bumetanide may increase the hypokalemic activities of Topiramate. The metabolism of Rosuvastatin can be decreased when combined with Topiramate. The therapeutic efficacy of Topiramate can be decreased when used in combination with Mianserin. The risk or severity of adverse effects can be increased when Topiramate is combined with Olopatadine. The risk or severity of adverse effects can be increased when Pancuronium is combined with Topiramate. The risk or severity of adverse effects can be increased when Methscopolamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Fluspirilene is combined with Topiramate. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. The metabolism of Zidovudine can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Promethazine. The metabolism of Proguanil can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Topiramate. The risk or severity of adverse effects can be increased when Loprazolam is combined with Topiramate. The metabolism of Adinazolam can be decreased when combined with Topiramate. The serum concentration of Estramustine can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Ziprasidone is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Amoxapine. The serum concentration of Estrone sulfate can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Ethotoin. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The risk or severity of adverse effects can be increased when Ecopipam is combined with Topiramate. The serum concentration of Estradiol can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Alaproclate. The risk or severity of adverse effects can be increased when Butylscopolamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Topiramate. The serum concentration of Ulipristal can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Allopregnanolone is combined with Topiramate. The risk or severity of adverse effects can be increased when Sertindole is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Desvenlafaxine. The risk or severity of adverse effects can be increased when Trazodone is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Nortriptyline. The serum concentration of Estrogens, esterified can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Halazepam is combined with Topiramate. The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Topiramate. The risk or severity of adverse effects can be increased when Zaleplon is combined with Topiramate. Indapamide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Topiramate. The metabolism of Clarithromycin can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Cyclopentolate is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Tolcapone. The risk or severity of adverse effects can be increased when Promazine is combined with Topiramate. The risk or severity of adverse effects can be increased when Heroin is combined with Topiramate. The metabolism of Esomeprazole can be decreased when combined with Topiramate. The metabolism of Tolbutamide can be decreased when combined with Topiramate. The serum concentration of Saxagliptin can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Chlorphenamine. The risk or severity of adverse effects can be increased when Topiramate is combined with Lamotrigine. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Ramelteon. The risk or severity of adverse effects can be increased when Normethadone is combined with Topiramate. The risk or severity of adverse effects can be increased when Quinidine is combined with Topiramate. The risk or severity of adverse effects can be increased when Methaqualone is combined with Topiramate. The risk or severity of adverse effects can be increased when Tramadol is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Entacapone. The risk or severity of adverse effects can be increased when Tiotropium is combined with Topiramate. The risk or severity of adverse effects can be increased when Thioridazine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Vigabatrin. Hydrochlorothiazide may increase the hypokalemic activities of Topiramate. The metabolism of Almotriptan can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Levocabastine. The risk or severity of adverse effects can be increased when Butalbital is combined with Topiramate. The risk or severity of adverse effects can be increased when Baclofen is combined with Topiramate. The risk or severity of adverse effects can be increased when Trichloroethylene is combined with Topiramate. The serum concentration of Dienestrol can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Dicyclomine is combined with Topiramate. The serum concentration of Methallenestril can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Methapyrilene is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Clemastine. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Fexofenadine. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Topiramate. The metabolism of Ospemifene can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when clomethiazole is combined with Topiramate. The metabolism of Trimethadione can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Topiramate. The serum concentration of Topiramate can be decreased when it is combined with Orlistat. The metabolism of Pantoprazole can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Benactyzine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Valproic Acid. The serum concentration of Hexestrol can be decreased when it is combined with Topiramate. The risk or severity of adverse effects can be increased when Trimethaphan is combined with Topiramate. Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Topiramate. The metabolism of Famotidine can be decreased when combined with Topiramate. Topiramate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Scopolamine is combined with Topiramate. The metabolism of Amoxicillin can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Brompheniramine. The risk or severity of adverse effects can be increased when Topiramate is combined with Clonazepam. The risk or severity of adverse effects can be increased when Pentazocine is combined with Topiramate. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Topiramate. The risk or severity of adverse effects can be increased when Dyclonine is combined with Topiramate. The metabolism of Ibuprofen can be decreased when combined with Topiramate. Torasemide may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Metixene is combined with Topiramate. The risk or severity of adverse effects can be increased when Atropine is combined with Topiramate. The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Topiramate. Topiramate may increase the sedative activities of Metyrosine. The risk or severity of adverse effects can be increased when Isoflurane is combined with Topiramate. The risk or severity of adverse effects can be increased when Flupentixol is combined with Topiramate. The risk or severity of adverse effects can be increased when Tandospirone is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Meclizine. The risk or severity of adverse effects can be increased when Pramocaine is combined with Topiramate. The risk or severity of adverse effects can be increased when Tubocurarine is combined with Topiramate. The risk or severity of adverse effects can be increased when Temazepam is combined with Topiramate. The risk or severity of adverse effects can be increased when Oxycodone is combined with Topiramate. Etacrynic acid may increase the hypokalemic activities of Topiramate. The risk or severity of adverse effects can be increased when Ondansetron is combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Dimenhydrinate. The risk or severity of adverse effects can be increased when Trospium is combined with Topiramate. The metabolism of Dapsone can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Topiramate is combined with Methsuximide. The metabolism of Omeprazole can be decreased when combined with Topiramate. The metabolism of Lansoprazole can be decreased when combined with Topiramate. The risk or severity of adverse effects can be increased when Gabapentin is combined with Topiramate.