The risk or severity of adverse effects can be increased when Agomelatine is combined with Pomalidomide. Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Ethanol. The risk or severity of adverse effects can be increased when Agomelatine is combined with Chlorzoxazone. The risk or severity of adverse effects can be increased when Butethal is combined with Agomelatine. The serum concentration of Agomelatine can be increased when it is combined with Midostaurin. The risk or severity of adverse effects can be increased when Halazepam is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Morphine is combined with Agomelatine. The serum concentration of Agomelatine can be increased when it is combined with Ticlopidine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Piritramide. The risk or severity of adverse effects can be increased when Methaqualone is combined with Agomelatine. The risk or severity of adverse effects can be increased when Zaleplon is combined with Agomelatine. Agomelatine may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Agomelatine is combined with Tiapride. Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Agomelatine. The risk or severity of adverse effects can be increased when Sevoflurane is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Phenoxyethanol. The risk or severity of adverse effects can be increased when Canertinib is combined with Agomelatine. Agomelatine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. Agomelatine may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Zotepine. The risk or severity of adverse effects can be increased when Mesoridazine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Flibanserin. The serum concentration of Agomelatine can be increased when it is combined with Nevirapine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Sertraline. The risk or severity of adverse effects can be increased when Agomelatine is combined with Lofentanil. The risk or severity of adverse effects can be increased when Prilocaine is combined with Agomelatine. Agomelatine may increase the sedative activities of Metyrosine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Allopregnanolone. The risk or severity of adverse effects can be increased when Ketamine is combined with Agomelatine. Droperidol may increase the central nervous system depressant (CNS depressant) activities of Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Trimipramine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Alphaprodine. The risk or severity of adverse effects can be increased when Dyclonine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Topiramate. The risk or severity of adverse effects can be increased when Tramadol is combined with Agomelatine. The risk or severity of adverse effects can be increased when Molindone is combined with Agomelatine. The risk or severity of adverse effects can be increased when Lurasidone is combined with Agomelatine. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Clonazepam. The risk or severity of adverse effects can be increased when Enflurane is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Alaproclate. The risk or severity of adverse effects can be increased when Thioridazine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Propofol is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Promethazine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Methocarbamol. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Trichloroethylene. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Imipramine. The risk or severity of adverse effects can be increased when Triazolam is combined with Agomelatine. The risk or severity of adverse effects can be increased when Fencamfamine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Lamotrigine. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Melatonin is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Clidinium. The risk or severity of adverse effects can be increased when Midazolam is combined with Agomelatine. The risk or severity of adverse effects can be increased when Aripiprazole is combined with Agomelatine. The risk or severity of adverse effects can be increased when Amisulpride is combined with Agomelatine. The risk or severity of adverse effects can be increased when Reserpine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Agomelatine. The risk or severity of adverse effects can be increased when Rufinamide is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Clobazam. The risk or severity of adverse effects can be increased when Agomelatine is combined with Cetirizine. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Agomelatine. The risk or severity of adverse effects can be increased when Thiothixene is combined with Agomelatine. Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Amoxapine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Brotizolam. The risk or severity of adverse effects can be increased when Proparacaine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Butamben. The risk or severity of adverse effects can be increased when Agomelatine is combined with Paroxetine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Perazine. The risk or severity of adverse effects can be increased when Deramciclane is combined with Agomelatine. The risk or severity of adverse effects can be increased when Desflurane is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Fospropofol. The risk or severity of adverse effects can be increased when Dezocine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Etorphine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Secobarbital is combined with Agomelatine. The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Normethadone. The risk or severity of adverse effects can be increased when Gabapentin is combined with Agomelatine. The serum concentration of Agomelatine can be increased when it is combined with Mexiletine. The serum concentration of Agomelatine can be increased when it is combined with Fluvoxamine. The therapeutic efficacy of Agomelatine can be increased when used in combination with Pregabalin. The risk or severity of adverse effects can be increased when Agomelatine is combined with Ketobemidone. The risk or severity of adverse effects can be increased when Halothane is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Baclofen. The risk or severity of adverse effects can be increased when Agomelatine is combined with Melperone. The risk or severity of adverse effects can be increased when Ondansetron is combined with Agomelatine. The risk or severity of adverse effects can be increased when Isoflurane is combined with Agomelatine. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Agomelatine. The risk or severity of adverse effects can be increased when Bromazepam is combined with Agomelatine. The risk or severity of adverse effects can be increased when Prazepam is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Tiagabine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Sepranolone. The risk or severity of adverse effects can be increased when Drotebanol is combined with Agomelatine. The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Oxethazaine. The risk or severity of adverse effects can be increased when Hexobarbital is combined with Agomelatine. The risk or severity of adverse effects can be increased when Amobarbital is combined with Agomelatine. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Olopatadine. The risk or severity of adverse effects can be increased when Methohexital is combined with Agomelatine. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Agomelatine. The risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Agomelatine. Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Agomelatine. The serum concentration of Agomelatine can be increased when it is combined with Lidocaine. The serum concentration of Agomelatine can be increased when it is combined with Caffeine. The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Ethyl chloride. The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Quetiapine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Opium. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Triprolidine. The risk or severity of adverse effects can be increased when Carfentanil is combined with Agomelatine. The risk or severity of adverse effects can be increased when Lithium is combined with Agomelatine. The risk or severity of adverse effects can be increased when Oxycodone is combined with Agomelatine. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Agomelatine. The serum concentration of Agomelatine can be increased when it is combined with Theophylline. The risk or severity of adverse effects can be increased when Pentobarbital is combined with Agomelatine. The risk or severity of adverse effects can be increased when Remoxipride is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Stiripentol. The risk or severity of adverse effects can be increased when Sufentanil is combined with Agomelatine. The risk or severity of adverse effects can be increased when Agomelatine is combined with Levomilnacipran. The risk or severity of adverse effects can be increased when Agomelatine is combined with Lormetazepam.