The therapeutic efficacy of Zonisamide can be decreased when used in combination with Mianserin. The risk or severity of adverse effects can be increased when Propoxycaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocabastine. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Brexpiprazole. The risk or severity of adverse effects can be increased when Amobarbital is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Mifepristone. The serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide. The risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tandospirone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. The risk or severity of adverse effects can be increased when Bromazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Sildenafil. The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Imipramine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Zonisamide is combined with Maprotiline. Zonisamide may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pramocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Triprolidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pentazocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pipotiazine. The risk or severity of adverse effects can be increased when Amitriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ziprasidone. The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methoxyflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxprenolol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prilocaine is combined with Zonisamide. Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Ketamine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Idelalisib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocetirizine. The metabolism of Zonisamide can be decreased when combined with Fluconazole. The risk or severity of adverse effects can be increased when Flurazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fluspirilene is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Siltuximab. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Aceprometazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Cyclizine. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Verapamil. The risk or severity of adverse effects can be increased when Gabapentin is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Bortezomib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levetiracetam. The metabolism of Zonisamide can be decreased when combined with Delavirdine. The serum concentration of Zonisamide can be decreased when it is combined with Phenobarbital. The serum concentration of Zonisamide can be increased when it is combined with Dasatinib. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Dabrafenib. The risk or severity of adverse effects can be increased when Trichloroethylene is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Lovastatin. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Canertinib is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. The metabolism of Zonisamide can be increased when combined with Rifabutin. The metabolism of Zonisamide can be decreased when combined with Itraconazole. The risk or severity of adverse effects can be increased when Baclofen is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Promethazine. The risk or severity of adverse effects can be increased when Reserpine is combined with Zonisamide. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Lurasidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trazodone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Venlafaxine. The metabolism of Zonisamide can be decreased when combined with Posaconazole. The metabolism of Zonisamide can be decreased when combined with Saquinavir. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Pregabalin. The risk or severity of adverse effects can be increased when Paliperidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etomidate is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol. The risk or severity of adverse effects can be increased when Mesoridazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nortriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dezocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The metabolism of Zonisamide can be increased when combined with Carbamazepine. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Osanetant is combined with Zonisamide. The risk or severity of adverse effects can be increased when Remoxipride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Difenoxin. The risk or severity of adverse effects can be increased when Zonisamide is combined with Iloperidone. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flunarizine. The metabolism of Zonisamide can be decreased when combined with Clotrimazole. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Sarilumab. The risk or severity of adverse effects can be increased when Norflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desloratadine. Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levorphanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Halazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levomilnacipran. The risk or severity of adverse effects can be increased when Tizanidine is combined with Zonisamide. Zonisamide may increase the sedative activities of Metyrosine. Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be decreased when combined with Imatinib. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Opium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Fosphenytoin. The risk or severity of adverse effects can be increased when Ethotoin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alphaprodine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dyclonine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Osimertinib. The risk or severity of adverse effects can be increased when Indiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Secobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Zonisamide. Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Proparacaine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fluvoxamine. The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amoxapine is combined with Zonisamide.