The risk or severity of adverse effects can be increased when Thiamylal is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine. The risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide. The risk or severity of adverse effects can be increased when DPDPE is combined with Zonisamide. The risk or severity of adverse effects can be increased when Efavirenz is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Cyclizine. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Zonisamide. Zonisamide may increase the sedative activities of Metyrosine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flibanserin. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clonazepam. The risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Zimelidine. The risk or severity of adverse effects can be increased when Ondansetron is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tiapride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flunarizine. The risk or severity of adverse effects can be increased when Butorphanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loprazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amoxapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Maprotiline. The risk or severity of adverse effects can be increased when Zonisamide is combined with Alaproclate. The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. Zonisamide may increase the sedative activities of Rotigotine. The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Olopatadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Brompheniramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methohexital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Raclopride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Cocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Procaine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Nelfinavir. The metabolism of Zonisamide can be decreased when combined with Verapamil. The risk or severity of adverse effects can be increased when Zaleplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Carbinoxamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flupentixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dapiprazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trimipramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Posaconazole. Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Buspirone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Sevoflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Melatonin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pentazocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Primidone. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gepirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zotepine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Fusidic Acid. The risk or severity of adverse effects can be increased when Zonisamide is combined with Escitalopram. The risk or severity of adverse effects can be increased when Vortioxetine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Isoflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Amiodarone. The serum concentration of Zonisamide can be decreased when it is combined with Orlistat. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desipramine. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Brotizolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trazodone is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline. The risk or severity of adverse effects can be increased when Meprobamate is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Fosphenytoin. The serum concentration of Zonisamide can be increased when it is combined with Palbociclib. The risk or severity of adverse effects can be increased when Ropivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxethazaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ramelteon. The risk or severity of adverse effects can be increased when Lithium is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Lumacaftor. The risk or severity of adverse effects can be increased when Mesoridazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Acepromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bromperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The serum concentration of Conivaptan can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dimenhydrinate. The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The risk or severity of adverse effects can be increased when Bromazepam is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Tocilizumab. The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etomidate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Risperidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desloratadine. The risk or severity of adverse effects can be increased when Pethidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thiothixene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Difenoxin. The risk or severity of adverse effects can be increased when Clidinium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Citalopram. The risk or severity of adverse effects can be increased when Paliperidone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. The metabolism of Zonisamide can be decreased when combined with Telaprevir. The serum concentration of Zonisamide can be increased when it is combined with Osimertinib. The risk or severity of adverse effects can be increased when Topiramate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifabutin. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol. The metabolism of Zonisamide can be decreased when combined with Ziprasidone. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tizanidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Molindone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pomalidomide.