The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Tasimelteon. The risk or severity of adverse effects can be increased when Articaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nitrazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Brexpiprazole. The risk or severity of adverse effects can be increased when Alfentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethotoin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Normethadone is combined with Zonisamide. Zonisamide may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Risperidone is combined with Zonisamide. The serum concentration of Cilostazol can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methocarbamol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Vortioxetine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Maprotiline. The risk or severity of adverse effects can be increased when Scopolamine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Triflupromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ranolazine. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be decreased when combined with Nefazodone. The metabolism of Zonisamide can be decreased when combined with Posaconazole. The risk or severity of adverse effects can be increased when Buspirone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Deramciclane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etifoxine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Raclopride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Triprolidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Aripiprazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. The metabolism of Zonisamide can be decreased when combined with Ketoconazole. The metabolism of Zonisamide can be decreased when combined with Fosamprenavir. The metabolism of Zonisamide can be decreased when combined with Doxycycline. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telaprevir. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The risk or severity of adverse effects can be increased when Butethal is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butabarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Propofol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Imatinib. The risk or severity of adverse effects can be increased when Ecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Zimelidine. The risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifabutin. The risk or severity of adverse effects can be increased when Remoxipride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sufentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Haloperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bromperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Milnacipran. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Enflurane is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Lumacaftor. The risk or severity of adverse effects can be increased when Ethosuximide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Saquinavir. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desipramine. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Sarilumab. The risk or severity of adverse effects can be increased when Cocaine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with St. John's Wort. The risk or severity of adverse effects can be increased when Zonisamide is combined with Cyclizine. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butamben is combined with Zonisamide. The risk or severity of adverse effects can be increased when Indiplon is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ziprasidone. The risk or severity of adverse effects can be increased when Fluphenazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Promazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Voriconazole. The risk or severity of adverse effects can be increased when Oxymorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Estazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gabapentin is combined with Zonisamide. Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine. The serum concentration of Zonisamide can be decreased when it is combined with Dabrafenib. The risk or severity of adverse effects can be increased when Tramadol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Olopatadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Netupitant. The risk or severity of adverse effects can be increased when Eszopiclone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Ropivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Asenapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dezocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loxapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Drotebanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nortriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Acepromazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Clotrimazole. The risk or severity of adverse effects can be increased when Quetiapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Rufinamide is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. The serum concentration of Zonisamide can be decreased when it is combined with Deferasirox. The serum concentration of Zonisamide can be increased when it is combined with Stiripentol. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Idelalisib. The risk or severity of adverse effects can be increased when Thiothixene is combined with Zonisamide. Zonisamide may increase the sedative activities of Rotigotine. The risk or severity of adverse effects can be increased when Flunitrazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Isavuconazonium. The serum concentration of Zonisamide can be decreased when it is combined with Siltuximab. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Osanetant is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Bortezomib. The risk or severity of adverse effects can be increased when Flurazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zopiclone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Isradipine. The serum concentration of Zonisamide can be decreased when it is combined with Tocilizumab. The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Venlafaxine. The metabolism of Zonisamide can be decreased when combined with Dihydroergotamine.