The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flupentixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clorazepate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dapiprazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Benzocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Etoperidone. The risk or severity of adverse effects can be increased when Zonisamide is combined with Cyclizine. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clozapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide. Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Loxapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tolcapone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levomilnacipran. The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Zonisamide. The serum concentration of Conivaptan can be increased when it is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. The risk or severity of adverse effects can be increased when Eltanolone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fluvoxamine. The metabolism of Zonisamide can be decreased when combined with Lovastatin. The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Ceritinib. The risk or severity of adverse effects can be increased when Ecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifapentine. The risk or severity of adverse effects can be increased when Deramciclane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desipramine. The serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide. The risk or severity of adverse effects can be increased when Amoxapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Nefazodone. The serum concentration of Zonisamide can be decreased when it is combined with Tocilizumab. The metabolism of Zonisamide can be increased when combined with Carbamazepine. The metabolism of Zonisamide can be increased when combined with Pentobarbital. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fexofenadine. The metabolism of Zonisamide can be decreased when combined with Itraconazole. The serum concentration of Zonisamide can be increased when it is combined with Luliconazole. The risk or severity of adverse effects can be increased when Zonisamide is combined with Tasimelteon. The risk or severity of adverse effects can be increased when Triflupromazine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Fosphenytoin. The risk or severity of adverse effects can be increased when Cocaine is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Lumacaftor. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Methsuximide. The metabolism of Zonisamide can be decreased when combined with Venlafaxine. The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Doxepin. The risk or severity of adverse effects can be increased when Proparacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Triprolidine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Erythromycin. The risk or severity of adverse effects can be increased when Etizolam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Olaparib. The risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methaqualone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine. The risk or severity of adverse effects can be increased when Tiagabine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butalbital is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. The risk or severity of adverse effects can be increased when Aceprometazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Bortezomib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pomalidomide. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bromazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Fluphenazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ketoconazole. The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Palbociclib. The risk or severity of adverse effects can be increased when Lithium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetracaine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Imatinib. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Alaproclate. The risk or severity of adverse effects can be increased when Thiamylal is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tiapride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethotoin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ondansetron is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methocarbamol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Posaconazole. The risk or severity of adverse effects can be increased when Etifoxine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levodopa. The risk or severity of adverse effects can be increased when Triazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dimenhydrinate. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine. The risk or severity of adverse effects can be increased when Ritanserin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desvenlafaxine. The risk or severity of adverse effects can be increased when Methadone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocetirizine. The metabolism of Zonisamide can be decreased when combined with Sulfisoxazole. The risk or severity of adverse effects can be increased when Imipramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Brexpiprazole. The risk or severity of adverse effects can be increased when Hexobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Norflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Atomoxetine. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Aripiprazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The risk or severity of adverse effects can be increased when Indiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Normethadone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketobemidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Efavirenz is combined with Zonisamide. The risk or severity of adverse effects can be increased when DPDPE is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zotepine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. The risk or severity of adverse effects can be increased when Rufinamide is combined with Zonisamide.