The risk or severity of adverse effects can be increased when Cetirizine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Eltanolone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Amiodarone. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ropivacaine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Delavirdine. The risk or severity of adverse effects can be increased when Eszopiclone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The metabolism of Zonisamide can be decreased when combined with Imatinib. The metabolism of Zonisamide can be decreased when combined with Isavuconazonium. The risk or severity of adverse effects can be increased when Haloperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Articaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lurasidone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Atomoxetine. The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Doxycycline. The serum concentration of Zonisamide can be decreased when it is combined with St. John's Wort. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pethidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thiamylal is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Tetrabenazine. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Difenoxin. The risk or severity of adverse effects can be increased when Molindone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Enflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clozapine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Rucaparib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pomalidomide. The metabolism of Zonisamide can be decreased when combined with Diltiazem. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levetiracetam. The risk or severity of adverse effects can be increased when Perphenazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Netupitant. The serum concentration of Zonisamide can be increased when it is combined with Simeprevir. The serum concentration of Zonisamide can be decreased when it is combined with Phenytoin. The serum concentration of Zonisamide can be decreased when it is combined with Vemurafenib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flibanserin. The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Allopregnanolone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Norflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thiopental is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Carbinoxamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Drotebanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Benperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Alaproclate. The serum concentration of Zonisamide can be increased when it is combined with Palbociclib. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifampicin. The risk or severity of adverse effects can be increased when Sulpiride is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The risk or severity of adverse effects can be increased when Proparacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Buspirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Risperidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pipamperone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alprazolam is combined with Zonisamide. Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pimozide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clonazepam. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Sarilumab. The serum concentration of Zonisamide can be increased when it is combined with Ivacaftor. The risk or severity of adverse effects can be increased when Fluspirilene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Zonisamide. Zonisamide may increase the sedative activities of Rotigotine. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Indalpine. The metabolism of Zonisamide can be decreased when combined with Clemastine. The risk or severity of adverse effects can be increased when Flunitrazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fencamfamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Zonisamide. The serum concentration of Cilostazol can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etifoxine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dapoxetine. The risk or severity of adverse effects can be increased when Amitriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The risk or severity of adverse effects can be increased when Alfentanil is combined with Zonisamide. Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Pregabalin. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxethazaine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Phenobarbital. The risk or severity of adverse effects can be increased when Zonisamide is combined with Cyclizine. Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be decreased when combined with Clarithromycin. The risk or severity of adverse effects can be increased when Oxprenolol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Scopolamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Rufinamide is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fosamprenavir. The risk or severity of adverse effects can be increased when Tetracaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desipramine. The risk or severity of adverse effects can be increased when Carisoprodol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Reserpine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Methoxyflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zotepine is combined with Zonisamide. Zonisamide may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Zaleplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Melatonin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Mesoridazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Isradipine. The metabolism of Zonisamide can be decreased when combined with Atazanavir. The risk or severity of adverse effects can be increased when Zonisamide is combined with Maprotiline. The metabolism of Zonisamide can be increased when combined with Nevirapine. The risk or severity of adverse effects can be increased when Hexobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methaqualone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lithium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Imipramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Olopatadine is combined with Zonisamide.