The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. The risk or severity of adverse effects can be increased when Zonisamide is combined with Felbamate. The risk or severity of adverse effects can be increased when Melperone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Promethazine. The risk or severity of adverse effects can be increased when Brotizolam is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Pregabalin. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Triprolidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Meprobamate is combined with Zonisamide. Zonisamide may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Zonisamide is combined with Tetrabenazine. The risk or severity of adverse effects can be increased when Nortriptyline is combined with Zonisamide. Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Deramciclane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The serum concentration of Zonisamide can be increased when it is combined with Netupitant. The risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amitriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfaxalone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Voriconazole. The risk or severity of adverse effects can be increased when Articaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfentanil is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Etifoxine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Venlafaxine. The serum concentration of Conivaptan can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trazodone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levocabastine. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Topiramate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethotoin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Doxycycline. The risk or severity of adverse effects can be increased when Fluspirilene is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ziprasidone. The risk or severity of adverse effects can be increased when Vortioxetine is combined with Zonisamide. Zonisamide may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ziconotide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Gabapentin Enacarbil. The risk or severity of adverse effects can be increased when Zotepine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Agomelatine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Rucaparib. The risk or severity of adverse effects can be increased when Bromazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Secobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lofentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Cyclizine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Maprotiline. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Asenapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methaqualone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bromperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Eltanolone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perazine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Deferasirox. The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tiapride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dapiprazole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dezocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Vemurafenib. The metabolism of Zonisamide can be decreased when combined with Fosamprenavir. The risk or severity of adverse effects can be increased when Perphenazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nitrazepam is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Ivacaftor. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Efavirenz is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desvenlafaxine. Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Phenobarbital. The metabolism of Zonisamide can be decreased when combined with Fluconazole. The risk or severity of adverse effects can be increased when Midazolam is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Orlistat. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Zonisamide. The risk or severity of adverse effects can be increased when Haloperidol is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Mifepristone. The risk or severity of adverse effects can be increased when Drotebanol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Nelfinavir. The metabolism of Zonisamide can be decreased when combined with Sulfisoxazole. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Osanetant is combined with Zonisamide. The risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide. Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be decreased when combined with Crizotinib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Perospirone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Sarilumab. The risk or severity of adverse effects can be increased when Ecopipam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Eszopiclone is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Aprepitant. The risk or severity of adverse effects can be increased when Olanzapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butalbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Osimertinib. The metabolism of Zonisamide can be decreased when combined with Atazanavir. The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. The risk or severity of adverse effects can be increased when Remifentanil is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. The risk or severity of adverse effects can be increased when Triazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clonidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cetirizine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine. The risk or severity of adverse effects can be increased when Fencamfamine is combined with Zonisamide.