The risk or severity of adverse effects can be increased when Ketazolam is combined with Zonisamide. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Sevoflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The metabolism of Zonisamide can be increased when combined with Nevirapine. The risk or severity of adverse effects can be increased when Lofentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Olaparib. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desloratadine. The risk or severity of adverse effects can be increased when Methaqualone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methylecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Atazanavir. The serum concentration of Zonisamide can be increased when it is combined with Osimertinib. The risk or severity of adverse effects can be increased when Triprolidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fospropofol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prilocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Reserpine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Procaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zopiclone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. The risk or severity of adverse effects can be increased when Imipramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trichloroethylene is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Sarilumab. The metabolism of Zonisamide can be decreased when combined with Nelfinavir. The risk or severity of adverse effects can be increased when Carisoprodol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pethidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dyclonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methohexital is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Carbamazepine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine. The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Dronedarone. The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Olanzapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Zimelidine. The serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Lorazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfaxalone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Indalpine. Zonisamide may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline. The serum concentration of Zonisamide can be increased when it is combined with Aprepitant. The risk or severity of adverse effects can be increased when Melatonin is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Orlistat. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zonisamide. Zonisamide may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Eszopiclone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ziprasidone. The risk or severity of adverse effects can be increased when Alphaprodine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Boceprevir. The risk or severity of adverse effects can be increased when Rufinamide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Norflurane is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine. The risk or severity of adverse effects can be increased when Oxymorphone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telithromycin. The risk or severity of adverse effects can be increased when Benperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxycodone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pipamperone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prazepam is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dezocine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide. The risk or severity of adverse effects can be increased when Buspirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butorphanol is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Mifepristone. The risk or severity of adverse effects can be increased when Zaleplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sepranolone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flibanserin. The risk or severity of adverse effects can be increased when Pentazocine is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Pregabalin. The serum concentration of Conivaptan can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lurasidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Molindone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. The risk or severity of adverse effects can be increased when Allopregnanolone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telaprevir. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The risk or severity of adverse effects can be increased when Methocarbamol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chloral hydrate is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Simeprevir. The metabolism of Zonisamide can be decreased when combined with Itraconazole. The risk or severity of adverse effects can be increased when Halazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perospirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Erythromycin. The risk or severity of adverse effects can be increased when Methoxyflurane is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fluvoxamine. The risk or severity of adverse effects can be increased when Thiopental is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amperozide is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Fosphenytoin. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Mianserin. The metabolism of Zonisamide can be increased when combined with Rifabutin. The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ezogabine. The risk or severity of adverse effects can be increased when Dextromoramide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Alaproclate. The risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Acepromazine is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Pentobarbital. The metabolism of Zonisamide can be decreased when combined with Sulfisoxazole. The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Netupitant. The serum concentration of Zonisamide can be decreased when it is combined with St. John's Wort. The metabolism of Zonisamide can be decreased when combined with Ranolazine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pipotiazine. The risk or severity of adverse effects can be increased when Etidocaine is combined with Zonisamide.