The serum concentration of Zonisamide can be decreased when it is combined with Phenobarbital. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. The risk or severity of adverse effects can be increased when Nitrazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Doxycycline. The metabolism of Zonisamide can be increased when combined with Lumacaftor. The metabolism of Zonisamide can be decreased when combined with Posaconazole. The metabolism of Zonisamide can be decreased when combined with Fluvoxamine. The risk or severity of adverse effects can be increased when Isoflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ecopipam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Articaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etizolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethosuximide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifampicin. The risk or severity of adverse effects can be increased when Clozapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amperozide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Benperidol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Indinavir. The metabolism of Zonisamide can be decreased when combined with Lovastatin. The risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ketoconazole. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Methsuximide. The risk or severity of adverse effects can be increased when Meprobamate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Nelfinavir. The risk or severity of adverse effects can be increased when Brotizolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Proparacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desipramine. The metabolism of Zonisamide can be decreased when combined with Atomoxetine. The risk or severity of adverse effects can be increased when Thiamylal is combined with Zonisamide. Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Loprazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fospropofol is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The risk or severity of adverse effects can be increased when Zonisamide is combined with Milnacipran. Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flibanserin. The metabolism of Zonisamide can be decreased when combined with Clotrimazole. The risk or severity of adverse effects can be increased when Piritramide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lurasidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levomilnacipran. The risk or severity of adverse effects can be increased when Methohexital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The risk or severity of adverse effects can be increased when Bromperidol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fosamprenavir. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Mianserin. The risk or severity of adverse effects can be increased when Tolcapone is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Tocilizumab. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tizanidine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Lopinavir. The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flupentixol is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Sarilumab. The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Enflurane is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Delavirdine. The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Difenoxin. The metabolism of Zonisamide can be increased when combined with Rifabutin. The risk or severity of adverse effects can be increased when Ondansetron is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flurazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Vortioxetine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Brompheniramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levetiracetam. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Nevirapine. Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Raclopride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Temazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prazepam is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Cyclosporine. The risk or severity of adverse effects can be increased when Halothane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Lamotrigine is combined with Zonisamide. Zonisamide may increase the sedative activities of Rotigotine. The risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide. Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Promethazine. The risk or severity of adverse effects can be increased when Amitriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dimenhydrinate. The risk or severity of adverse effects can be increased when Zonisamide is combined with Indalpine. The risk or severity of adverse effects can be increased when Clonidine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Olaparib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Iloperidone. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Etoperidone. The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. The risk or severity of adverse effects can be increased when Sulpiride is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Verapamil. The risk or severity of adverse effects can be increased when Zonisamide is combined with Zimelidine. The risk or severity of adverse effects can be increased when Levorphanol is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Dronedarone. The serum concentration of Zonisamide can be increased when it is combined with Ceritinib. The serum concentration of Zonisamide can be increased when it is combined with Ivacaftor. The metabolism of Zonisamide can be decreased when combined with Voriconazole. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Simeprevir. The risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perphenazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Telaprevir. The risk or severity of adverse effects can be increased when Risperidone is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Bosentan. The risk or severity of adverse effects can be increased when Tiapride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Tetrabenazine. The metabolism of Zonisamide can be decreased when combined with Isradipine. Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Adipiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perospirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Aceprometazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Itraconazole. The risk or severity of adverse effects can be increased when Normethadone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quetiapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levodopa. The risk or severity of adverse effects can be increased when Tiagabine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Sertraline.