The serum concentration of Zonisamide can be increased when it is combined with Osimertinib. The metabolism of Zonisamide can be decreased when combined with Diltiazem. The risk or severity of adverse effects can be increased when Levorphanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dantrolene. The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxymorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desvenlafaxine. The risk or severity of adverse effects can be increased when Opium is combined with Zonisamide. The risk or severity of adverse effects can be increased when Enflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Zonisamide. The serum concentration of Cilostazol can be increased when it is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Lopinavir. The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methocarbamol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Glutethimide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Etoperidone. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Trimipramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Felbamate. The risk or severity of adverse effects can be increased when DPDPE is combined with Zonisamide. The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Posaconazole. The risk or severity of adverse effects can be increased when Zonisamide is combined with Chlorphenamine. The risk or severity of adverse effects can be increased when Tandospirone is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. The risk or severity of adverse effects can be increased when Ethosuximide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butorphanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amoxapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amperozide is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fosamprenavir. The risk or severity of adverse effects can be increased when Zaleplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pipotiazine. The serum concentration of Zonisamide can be increased when it is combined with Mifepristone. The metabolism of Zonisamide can be decreased when combined with Crizotinib. The risk or severity of adverse effects can be increased when Butabarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ramelteon. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pomalidomide. The serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide. The risk or severity of adverse effects can be increased when Bromperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Triazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Diazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Meclizine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. The risk or severity of adverse effects can be increased when Flunitrazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Thioridazine is combined with Zonisamide. Zonisamide may increase the sedative activities of Ropinirole. The risk or severity of adverse effects can be increased when Zonisamide is combined with Milnacipran. The metabolism of Zonisamide can be decreased when combined with Nilotinib. The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Methohexital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Osanetant is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifapentine. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Pregabalin. Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Ethotoin is combined with Zonisamide. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Sildenafil. The risk or severity of adverse effects can be increased when Remoxipride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ropivacaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Etizolam is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Lumacaftor. The risk or severity of adverse effects can be increased when Ketamine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Dronedarone. The risk or severity of adverse effects can be increased when Valproic Acid is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clorazepate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tolcapone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Verapamil. Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Entacapone is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Dabrafenib. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Promethazine. The risk or severity of adverse effects can be increased when Nortriptyline is combined with Zonisamide. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Doxepin. The risk or severity of adverse effects can be increased when Ketobemidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Bortezomib. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. Zonisamide may increase the sedative activities of Pramipexole. The risk or severity of adverse effects can be increased when Fentanyl is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The risk or severity of adverse effects can be increased when Methapyrilene is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Clarithromycin. The risk or severity of adverse effects can be increased when Perazine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Boceprevir. The risk or severity of adverse effects can be increased when Triprolidine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Phenytoin. Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Flupentixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gepirone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Propoxycaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfaxalone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Duloxetine. The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Carbamazepine. The risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Ketoconazole. The risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fencamfamine is combined with Zonisamide. The serum concentration of Zonisamide can be decreased when it is combined with Bosentan. The risk or severity of adverse effects can be increased when Haloperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Gabapentin Enacarbil. The serum concentration of Zonisamide can be decreased when it is combined with Vemurafenib. The risk or severity of adverse effects can be increased when Lormetazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Olopatadine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Dapoxetine. The risk or severity of adverse effects can be increased when Lurasidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tiagabine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Palbociclib. The risk or severity of adverse effects can be increased when Adipiplon is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetracaine is combined with Zonisamide.