The metabolism of Zonisamide can be increased when combined with Rifampicin. The serum concentration of Zonisamide can be decreased when it is combined with Vemurafenib. The risk or severity of adverse effects can be increased when Zonisamide is combined with Levetiracetam. The risk or severity of adverse effects can be increased when Lofentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Trazodone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pramocaine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. The risk or severity of adverse effects can be increased when Raclopride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ondansetron is combined with Zonisamide. The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Morphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Brompheniramine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxymorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ecgonine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amobarbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Drotebanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Triazolam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Citalopram. The risk or severity of adverse effects can be increased when Tetracaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Amperozide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Asenapine is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Ceritinib. The risk or severity of adverse effects can be increased when Butethal is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Zimelidine. The risk or severity of adverse effects can be increased when Chlormezanone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sertindole is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Rifapentine. The risk or severity of adverse effects can be increased when Nitrous oxide is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clonidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Efavirenz is combined with Zonisamide. The risk or severity of adverse effects can be increased when Olopatadine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Bortezomib. The metabolism of Zonisamide can be decreased when combined with Cobicistat. The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Zonisamide. The risk or severity of adverse effects can be increased when Bromperidol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Quetiapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Clozapine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Paroxetine. The risk or severity of adverse effects can be increased when Butalbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Desvenlafaxine. The risk or severity of adverse effects can be increased when Amisulpride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fencamfamine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Mepivacaine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. The serum concentration of Zonisamide can be decreased when it is combined with Mitotane. The risk or severity of adverse effects can be increased when Deramciclane is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Diltiazem. The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Alfaxalone is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Voriconazole. The risk or severity of adverse effects can be increased when Protriptyline is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Atomoxetine. The risk or severity of adverse effects can be increased when Propofol is combined with Zonisamide. Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Nalbuphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Reserpine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxethazaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Hexobarbital is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Lopinavir. The metabolism of Zonisamide can be decreased when combined with Darunavir. The risk or severity of adverse effects can be increased when Cetirizine is combined with Zonisamide. Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Methohexital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Butorphanol is combined with Zonisamide. The risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Primidone. The risk or severity of adverse effects can be increased when Eltanolone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Flunarizine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Ziconotide. The risk or severity of adverse effects can be increased when Risperidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tolcapone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Zonisamide. Magnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Melperone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Isoflurane is combined with Zonisamide. The risk or severity of adverse effects can be increased when Barbital is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Clomipramine. The risk or severity of adverse effects can be increased when Zonisamide is combined with Guanfacine. The risk or severity of adverse effects can be increased when Sepranolone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Heroin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Remifentanil is combined with Zonisamide. The risk or severity of adverse effects can be increased when Molindone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Pipotiazine. The risk or severity of adverse effects can be increased when Vortioxetine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Normethadone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Zonisamide. The metabolism of Zonisamide can be increased when combined with Nevirapine. The risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide. The therapeutic efficacy of Zonisamide can be decreased when used in combination with Mefloquine. The risk or severity of adverse effects can be increased when Pipamperone is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Aprepitant. The serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant. The risk or severity of adverse effects can be increased when Zotepine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Propoxycaine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Ketobemidone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Desflurane is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Dronedarone. The risk or severity of adverse effects can be increased when Fludiazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Oxazepam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Etoperidone. The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Codeine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Sulpiride is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Zonisamide. The metabolism of Zonisamide can be decreased when combined with Fluconazole. The risk or severity of adverse effects can be increased when Pethidine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Zonisamide is combined with Fluoxetine. The risk or severity of adverse effects can be increased when Etorphine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tramadol is combined with Zonisamide. The risk or severity of adverse effects can be increased when DPDPE is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Dasatinib. The risk or severity of adverse effects can be increased when Ethyl chloride is combined with Zonisamide. The serum concentration of Zonisamide can be increased when it is combined with Stiripentol. The risk or severity of adverse effects can be increased when Clobazam is combined with Zonisamide. The risk or severity of adverse effects can be increased when Aceprometazine is combined with Zonisamide. Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zonisamide. The risk or severity of adverse effects can be increased when Hydromorphone is combined with Zonisamide. The risk or severity of adverse effects can be increased when Fluphenazine is combined with Zonisamide. The risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Zonisamide. The risk or severity of adverse effects can be increased when Perphenazine is combined with Zonisamide. The serum concentration of Cilostazol can be increased when it is combined with Zonisamide. The risk or severity of adverse effects can be increased when Pentazocine is combined with Zonisamide. The serum concentration of Conivaptan can be increased when it is combined with Zonisamide.