Drug combination: Tramabene & Diclofenac duo pharmaswiss & Sertivan & Lyrica

Compared drugs
Tramabene (tramadol)
Diclofenac duo pharmaswiss (diclofenac)
Sertivan (sertraline)
Lyrica (pregabalin)

Drug Interaction

Tramabene & Sertivan
Sertraline may increase the neuroexcitatory activities of Tramadol.

Tramabene & Lyrica
The therapeutic efficacy of Tramadol can be increased when used in combination with Pregabalin.

Diclofenac duo pharmaswiss & Sertivan
The metabolism of Diclofenac can be decreased when combined with Sertraline.

Sertivan & Lyrica
The risk or severity of adverse effects can be increased when Pregabalin is combined with Sertraline.

Food interactions and other recommendations

Tramabene: Oral administration of tramadol hydrochloride with food does not significantly affect its rate or extent of absorption, therefore, tramadol hydrochloride can be administered without regard to food.
Diclofenac duo pharmaswiss: Avoid alcohol. Take with food to reduce irritation.
Sertivan: Avoid alcohol. Avoid St.John's Wort. Avoid taking with grapefruit juice. Take with food.
Lyrica: Avoid alcohol (may increase CNS effects). When taken with food, Cmax decreases, while Tmax is prolonged. Despite these observations, the total absorption of pregabalin is not effected to a clinically relevant degree. Pregabalin can be taken with or without food.

Combination of side effects

Combination of common side effects of all medicines

Abdominal Pain
Tramabene (uncommon)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (common)

Anorexia
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (very common)
Lyrica (common)

Arthralgia
Tramabene (uncommon)
Diclofenac duo pharmaswiss (very common)
Sertivan (uncommon)
Lyrica (common)

Asthenia
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (common)
Lyrica (very common)

Constipation
Tramabene (very common)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (very common)

Diarrhea
Tramabene (common)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (common)

Dizziness
Tramabene (very common)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (very common)

dyspnea
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (common)

Flatulence
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (common)
Lyrica (common)

Headache
Tramabene (very common)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (very common)

allergic reactions
Tramabene (common)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (common)
Lyrica (common)

Hypertension
Tramabene (common)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (common)

arthropathy
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (uncommon)

Nausea
Tramabene (very common)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (very common)

Pain
Tramabene (uncommon)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (common)

paresthesia
Tramabene (uncommon)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (common)
Lyrica (common)

Itching
Tramabene (common)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (common)
Lyrica (common)

Sinusitis
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (common)

urticaria
Tramabene (uncommon)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (common)
Lyrica (uncommon)

vertigo
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (uncommon)

Vomiting
Tramabene (very common)
Diclofenac duo pharmaswiss (common)
Sertivan (common)
Lyrica (common)

Migraine
Tramabene (uncommon)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (uncommon)

eye pain
Tramabene (uncommon)
Diclofenac duo pharmaswiss (common)
Sertivan (uncommon)
Lyrica (uncommon)

Dry skin
Tramabene (uncommon)
Diclofenac duo pharmaswiss (very common)
Sertivan (common)
Lyrica (uncommon)

Myalgia
Tramabene (uncommon)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (common)
Lyrica (common)

Somnolence
Tramabene (very common)
Diclofenac duo pharmaswiss (uncommon)
Sertivan (uncommon)
Lyrica (very common)

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