Drug combination: Wobenzym & Trombex & Lanzul & Prestance & Tulip
Compared drugs
Wobenzym (trypsin, combinations)
Trombex (clopidogrel)
Lanzul (lansoprazole)
Prestance (perindopril and amlodipine)
Tulip (atorvastatin)
Wobenzym (trypsin, combinations)
Trombex (clopidogrel)
Lanzul (lansoprazole)
Prestance (perindopril and amlodipine)
Tulip (atorvastatin)
Trombex & Lanzul
The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Lansoprazole resulting in a loss in efficacy.
The serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Lansoprazole resulting in a loss in efficacy.
Trombex & Prestance
The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Amlodipine.
The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Amlodipine.
Lanzul & Tulip
The risk or severity of adverse effects can be increased when Lansoprazole is combined with Atorvastatin.
The risk or severity of adverse effects can be increased when Lansoprazole is combined with Atorvastatin.
Prestance & Tulip
The risk or severity of adverse effects can be increased when Amlodipine is combined with Atorvastatin.
The risk or severity of adverse effects can be increased when Amlodipine is combined with Atorvastatin.
Lanzul: Avoid alcohol. Food reduces bioavailabilty, but this has very little clinical impact. Take 30-60 minutes before meals.
Prestance: Avoid natural licorice. Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication. Take without regard to meals.
Tulip: Avoid alcohol. Avoid drastic changes in dietary habit. Avoid taking grapefruit or grapefruit juice throughout treatment. Grapefruit can significantly increase serum levels of this product. Food may decrease maximum plasma levels and area under the curve, but this is clinically inconsequential according to the manufacturer. Take with low fat meal.
Prestance: Avoid natural licorice. Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication. Take without regard to meals.
Tulip: Avoid alcohol. Avoid drastic changes in dietary habit. Avoid taking grapefruit or grapefruit juice throughout treatment. Grapefruit can significantly increase serum levels of this product. Food may decrease maximum plasma levels and area under the curve, but this is clinically inconsequential according to the manufacturer. Take with low fat meal.
For some of the comparators, there is not enough information available, contact us by email and we will list the side effects additionally
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